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题目:: Most microbe-specific naïve CD4⁺ T cells produce memory cells during infection.
作者:: Tubo(Noah J),Fife(Brian T),Pagan(Antonio J),Kotov(Dmitri I),Goldberg(Michael F),Jenkins(Marc K)
状态:: 发布时间2016-01-29 , 更新时间 2016-10-25
期刊:: Science
摘要:: Infection elicits CD4(+) memory T lymphocytes that participate in protective immunity. Although memory cells are the progeny of naïve T cells, it is unclear that all naïve cells from a polyclonal repertoire have memory cell potential. Using a single-cell adoptive transfer and spleen biopsy method, we found that in mice, essentially all microbe-specific naïve cells produced memory cells during infection. Different clonal memory cell populations had different B cell or macrophage helper compositions that matched effector cell populations generated much earlier in the response. Thus, each microbe-specific naïve CD4(+) T cell produces a distinctive ratio of effector cell types early in the immune response that is maintained as some cells in the clonal population become memory cells.
语言:: eng
DOI:

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