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PMID: 2682265 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish.

Nature ·Vol. 342 ·No. 6247 ·1989-11-16 ·Pages 238-43

Kelsoe JR, Ginns EI, Egeland JA, Gerhard DS, Goldstein AM, Bale SJ, Pauls DL, Long RT, Kidd KK, Conte G

Abstract

Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.

MeSH Terms
Bipolar Disorder/diagnosis,genetics Chromosomes, Human, Pair 11 Ethnicity Genes, ras Genetic Linkage Genotype Humans Insulin/genetics Pedigree Pennsylvania
Chemicals
Insulin
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Kelsoe J R
Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20892.
Ginns E I
Egeland J A
Gerhard D S
Goldstein A M
Bale S J
Pauls D L
Long R T
Kidd K K
Conte G
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/342238a0
Published
1989-11-16
Pages
238-43
Language
English
Region
England
NLM ID
0410462
Subset
IM
Corrections
CommentIn
PMID: 2812021
External Links
PubMed source DOI: 10.1038/342238a0 View journal details
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