Abstract
Age-related cataract is among the most common chronic disorders of ageing and is the world's leading blinding disorder. Long non-coding RNAs play important roles in several biological processes and complicated diseases. However, the role of lncRNAs in the setting of cataract is still unknown. Here, we extracted total RNAs from the transparent and age-matched cataractous human lenses, and determined lncRNA expression profiles using microarray analysis. We found that 38 lncRNAs were differentially expressed between transparent and cataractous lenses. 17 of 20 differentially expressed lncRNAs were further verified by quantitative RT-PCRs. One top abundant lncRNA, MIAT, was specifically up-regulated both in the plasma fraction of whole blood and aqueous humor of cataract patients. MIAT knockdown could affect the proliferation, apoptosis and migration of Human lens epithelial cells (HLECs) upon oxidative stress. Posterior capsule opacification (PCO) is a common complication of cataract surgery, which is associated with abnormal production of inflammatory factors. MIAT knockdown could repress tumour necrosis factor-α-induced abnormal proliferation and migration of HLECs, suggesting a potential role of MIAT in PCO-related pathological process. Moreover, we found that MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR-150-5p to regulate HLEC function. Collectively, this study provides a novel insight into the pathogenesis of age-related cataract.
Keywords
cataract
cell migration
cell viability
circulating RNA
long non-coding RNA
MeSH Terms
Aged
Apoptosis
Biomarkers/metabolism
Cataract/metabolism,pathology
Cell Line
Cell Movement
Cell Proliferation
Epithelial Cells/physiology
Female
Gene Expression
Humans
Lens, Crystalline/pathology
Male
MicroRNAs/metabolism
Middle Aged
Proto-Oncogene Proteins c-akt/metabolism
RNA, Long Noncoding/physiology
Up-Regulation
Chemicals
Biomarkers
MIRN150 microRNA, human
Miat long non-coding RNA
MicroRNAs
RNA, Long Noncoding
Proto-Oncogene Proteins c-akt
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Shen Yi
Eye Hospital, Nanjing Medical University, Nanjing, China.
Dong Ling-Feng
Eye Hospital, Nanjing Medical University, Nanjing, China. | The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Zhou Rong-Mei
Eye Hospital, Nanjing Medical University, Nanjing, China. | The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Yao Jin
Eye Hospital, Nanjing Medical University, Nanjing, China. | The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Song Yu-Chen
The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Yang Hong
The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Jiang Qin
Eye Hospital, Nanjing Medical University, Nanjing, China. | The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Yan Biao
The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
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