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PMID: 2675423 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Trans splicing in trypanosomes--archaism or adaptation?

Trends in genetics : TIG ·Vol. 5 ·No. 7 ·1989-07-00 ·Pages 204-8

Laird PW

Abstract

In trypanosomes, a single transcription unit usually covers several protein-coding genes. The primary transcript is cut up by trans-splicing and polyadenylation machineries to generate individual mature mRNAs. All nuclear mRNAs acquire the same capped 39 nucleotide sequence at their 5' end as a consequence of the trans-splicing event. Trans splicing is used in the synthesis of some mRNAs in nematodes and chloroplasts. These unusual systems are clearly related to cis-splicing systems, but it remains an intriguing question whether they are merely exotic offshoots of cis splicing or archaic remnants of cis-splicing progenitors.

MeSH Terms
Adaptation, Biological Animals Biological Evolution RNA Splicing Trypanosoma/genetics,metabolism
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Laird P W
References (29)
29 references, click to expand
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Article Info
Journal
Trends in genetics : TIG
Abbr.
Trends Genet
ISSN
0168-9525
DOI
10.1016/0168-9525(89)90082-6
Published
1989-07-00
Pages
204-8
Language
English
Region
England
NLM ID
8507085
PMCID
PMC7134362
Subset
IM
External Links
PubMed source DOI: 10.1016/0168-9525(89)90082-6 PMC Full Text View journal details
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