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PMID: 2674680 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

Molecular and cellular biology ·Vol. 9 ·No. 7 ·1989-07-00 ·Pages 3114-6

van 't Veer LJ, Burgering BM, Versteeg R, Boot AJ, Ruiter DJ, Osanto S, Schrier PI, Bos JL

Abstract

In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested.

MeSH Terms
DNA, Neoplasm/genetics Female Gene Expression Regulation Genes, ras Humans Male Melanoma/genetics,pathology,secondary Mutation Skin Neoplasms/genetics,pathology,secondary Sunlight/adverse effects Tumor Cells, Cultured Ultraviolet Rays/adverse effects
Chemicals
DNA, Neoplasm
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
van 't Veer L J
Department of Clinical Oncology, Leiden University Hospital, The Netherlands.
Burgering B M
Versteeg R
Boot A J
Ruiter D J
Osanto S
Schrier P I
Bos J L
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.9.7.3114-3116.1989
Published
1989-07-00
Pages
3114-6
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC362784
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.9.7.3114-3116.1989 PMC Full Text View journal details
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