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PMID: 2669684 Published · ppublish English Journal Article Review

Morphogenesis and morphology of HIV. Structure-function relations.

Archives of virology ·Vol. 106 ·No. 1-2 ·1989-00-00 ·Pages 1-13

Gelderblom HR, Ozel M, Pauli G

Abstract

Fine structure and antigenic make-up analysis of HIV were combined in a 2D model, from which functional aspects can be deduced. On the envelope 72 probably trimeric surface knobs (gp120) are connected to the virion via the transmembrane protein gp41. Gp120 is shed during ageing of the virion, but host cell antigens stay firmly anchored to the envelope. Underneath the envelope, p17 forms the matrix protein layer, while the capsid of the double cone shaped core is built up of p24. The relation between biochemical findings and morphogenesis and maturation of HIV as well as aspects of pathogenesis and vaccination are discussed.

MeSH Terms
Forecasting HIV/immunology,physiology,ultrastructure HIV Antigens/immunology Morphogenesis Retroviridae Proteins/immunology,metabolism Viral Proteins/immunology Viral Structural Proteins Viral Vaccines/immunology Virion/ultrastructure Virus Replication
Chemicals
HIV Antigens Retroviridae Proteins Viral Proteins Viral Structural Proteins Viral Vaccines
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gelderblom H R
Robert Koch-Institut, Berlin.
Ozel M
Pauli G
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01311033
Published
1989-00-00
Pages
1-13
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01311033 View journal details
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