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PMID: 26557472 Published · ppublish English Journal Article

Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside.

Current pharmacology reports ·Vol. 1 ·No. 6 ·2015-11-01 ·Pages 382-390

Amjad AI, Parikh RA, Appleman LJ, Hahm ER, Singh K, Singh SV

Abstract

Sulforaphane (SFN) is a metabolic by product of cruciferous vegetables and is the biologically active phytochemical found in high concentrations in broccoli. It has been studied extensively for its anticancer efficacy and the underlying mechanisms using cell culture and preclinical models. The immediate precursor of SFN is glucoraphanin, a glucosinolate which requires metabolic conversion to SFN. SFN and other notable isothiocyanates, including phenethyl isothiocyanate and benzyl isothiocyanate found in various cruciferous vegetables, have also been implicated to have a chemopreventive role for breast, colon and prostate cancer. In-vitro and in-vivo anti-cancer activity of this class of compounds summarizing the past two decades of basic science research has previously been reviewed by us and others. The present review aims to focus specifically on SFN and its chemopreventive and antineoplastic activity against prostate cancer. Particular emphasis in this communication is placed on the current status of clinical research and prospects for future clinical trials with the overall objective to better understand the clinical utility of this promising chemopreventive nutraceutical in the context of mechanisms of prostate carcinogenesis.

Keywords
Chemoprevention Prostate cancer Sulforaphane
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Amjad Ali I
Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania ; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Parikh Rahul A
Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania ; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Appleman Leonard J
Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania ; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Hahm Eun-Ryeong
University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania ; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Singh Kamayani
University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Singh Shivendra V
University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania ; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Article Info
Journal
Current pharmacology reports
Abbr.
Curr Pharmacol Rep
ISSN
2198-641X
Published
2015-11-01
Epub
2015-00-16
Pages
382-390
Language
English
Region
Switzerland
NLM ID
101649562
PMCID
PMC4635516
Grants
NCI NIH HHS · R01 CA115498 · United States
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