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题目:: Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave.
作者:: Shoaib(Muhammad),Sørensen(Claus Storgaard)
状态:: 发布时间2015-11-11 , 更新时间 2015-11-11
期刊:: Cancer Cell
摘要:: Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.
语言:: eng
DOI:: 10.1016/j.ccell.2015.10.009

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