| GeneLibs

题目:: [Molecular Mechanism and Malignant Clonal Evolution of Multiple Myeloma].
作者:: Ding(Fei),Zhu(Ping),Wu(Xue-Qiang)
状态:: 发布时间2015-11-03 , 更新时间 2016-10-18
期刊:: Zhongguo Shi Yan Xue Ye Xue Za Zhi
摘要:: Almost all patients with multiple myeloma (MM) have chromosomal translocation which can result in genetic variation. There are mainly five types of chromosomal translocations, involving the IGH gene translocation to 11q13 (CCND1), 4p16 (FGFR/MMSET), 16q23 (MAF), 6p21 (CCND3) and 20q11 (MAFB). It is possible that all IGH translocations converge on a common cell cycle signal pathway. Some MM develops through a multistep transformation from monoclonal gammopathy of undetermined significance (MGUS) to smoldering MM (SMM) and eventually to MM and plasma cell leukemia (PCL). Similarly to what Darwin proposed in the mid-19th century-random genetic variation and natural selection in the context of limited resources, MM clonal evolution follow branching and nonlinear mode. The failure of MM treatment is usually related with the minimal subclone which is hardly found at newlydiagnosed.
语言:: chi
DOI:

文献库文献相关信息