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题目:: Crosstalk between stem cell and cell cycle machineries.
作者:: Kareta(Michael S),Sage(Julien),Wernig(Marius)
状态:: 发布时间2015-12-21 , 更新时间 2016-12-01
期刊:: Curr Opin Cell Biol
摘要:: Pluripotent stem cells, defined by an unlimited self-renewal capacity and an undifferentiated state, are best typified by embryonic stem cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid progression through the cell cycle and a minimal time spent in G1. Recent reports indicate that pluripotency and cell cycle regulation are mechanistically linked. In this review, we discuss the reciprocal co-regulation of these processes, how this co-regulation may prevent differentiation, and how cellular reprogramming can re-establish the unique cell cycle regulation in induced pluripotent stem cells.
语言:: eng
DOI:

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