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题目:: Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death.
作者:: Florey(O),Kim(S E),Overholtzer(M)
状态:: 发布时间2015-11-10 , 更新时间 2016-11-10
期刊:: Curr Mol Med
摘要:: Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.
语言:: eng
DOI:

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