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题目:: Regulation of cell proliferation by hypoxia-inducible factors.
作者:: Hubbi(Maimon E),Semenza(Gregg L)
状态:: 发布时间2015-12-16 , 更新时间 2016-10-19
期刊:: Am J Physiol Cell Physiol
摘要:: Hypoxia is a physiological cue that impacts diverse physiological processes, including energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O2 demand, would only exacerbate hypoxic stress. However, certain cell populations maintain cell proliferation in the face of hypoxia. This is a common pathological hallmark of cancers, but can also serve a physiological function, as in the maintenance of stem cell populations that reside in a hypoxic niche. This review will discuss major molecular mechanisms by which hypoxia regulates cell proliferation in different cell populations, with a particular focus on the role of hypoxia-inducible factors.
语言:: eng
DOI:

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