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PMID: 2647894 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Induction of classical transplantation tolerance in the adult.

The Journal of experimental medicine ·Vol. 169 ·No. 3 ·1989-03-01 ·Pages 779-94

Qin SX, Cobbold S, Benjamin R, Waldmann H

Abstract

Transplantation tolerance across histoincompatibilities in multiple non-H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state was confirmed by permanent acceptance of donor strain skin grafts, and in vitro unresponsiveness to donor cells. Tolerance was associated with partial donor chimerism to various degrees. Tolerance to minor transplantation antigens induced in this manner was restricted to recipient-type MHC. The possibility was raised that tolerance resulted, at least in part, from clonal anergy rather than deletion.

MeSH Terms
Animals Antibodies, Monoclonal/therapeutic use Antigens, Differentiation, T-Lymphocyte/immunology Bone Marrow Transplantation Chimera Genes, Immunoglobulin Graft Rejection H-2 Antigens/immunology Immune Tolerance Immunoglobulin Fab Fragments Isoantigens/immunology Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, Inbred CBA Rats Receptors, Antigen, T-Cell/immunology Skin Transplantation T-Lymphocytes/immunology Transplantation Immunology
Chemicals
Antibodies, Monoclonal Antigens, Differentiation, T-Lymphocyte H-2 Antigens Immunoglobulin Fab Fragments Isoantigens Receptors, Antigen, T-Cell
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Qin S X
Department of Pathology, University of Cambridge, United Kingdom.
Cobbold S
Benjamin R
Waldmann H
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28 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.169.3.779
Published
1989-03-01
Pages
779-94
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189271
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1084/jem.169.3.779 PMC Full Text View journal details
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