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题目:: Cell-to-cell infection by HIV contributes over half of virus infection.
作者:: Iwami(Shingo),Takeuchi(Junko S),Nakaoka(Shinji),Mammano(Fabrizio),Clavel(François),Inaba(Hisashi),Kobayashi(Tomoko),Misawa(Naoko),Aihara(Kazuyuki),Koyanagi(Yoshio),Sato(Kei)
状态:: 发布时间2015-10-07 , 更新时间 2015-10-08
期刊:: Elife
摘要:: Cell-to-cell viral infection, in which viruses spread through contact of infected cell with surrounding uninfected cells, has been considered as a critical mode of virus infection. However, since it is technically difficult to experimentally discriminate the two modes of viral infection, namely cell-free infection and cell-to-cell infection, the quantitative information that underlies cell-to-cell infection has yet to be elucidated, and its impact on virus spread remains unclear. To address this fundamental question in virology, we quantitatively analyzed the dynamics of cell-to-cell and cell-free human immunodeficiency virus type 1 (HIV-1) infections through experimental-mathematical investigation. Our analyses demonstrated that the cell-to-cell infection mode accounts for approximately 60% of viral infection, and this infection mode shortens the generation time of viruses by 0.9 times and increases the viral fitness by 3.9 times. Our results suggest that even a complete block of the cell-free infection would provide only a limited impact on HIV-1 spread.
语言:: eng
DOI:

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