| GeneLibs

题目:: Mast-Cell-Derived TNF Amplifies CD8(+) Dendritic Cell Functionality and CD8(+) T Cell Priming.
作者:: Dudeck(Jan),Ghouse(Shanawaz Mohammed),Lehmann(Christian H K),Hoppe(Anja),Schubert(Nadja),Nedospasov(Sergei A),Dudziak(Diana),Dudeck(Anne)
状态:: 发布时间2015-10-15 , 更新时间 2015-10-15
期刊:: Cell Rep
摘要:: Mast cells are critical promoters of adaptive immunity in the contact hypersensitivity model, but the mechanism of allergen sensitization is poorly understood. Using Mcpt5-CreTNF(FL/FL) mice, we show here that the absence of TNF exclusively in mast cells impaired the expansion of CD8(+) T cells upon sensitization and the T-cell-driven adaptive immune response to elicitation. T cells primed in the absence of mast cell TNF exhibited a diminished efficiency to transfer sensitization to naive recipients. Specifically, mast cell TNF promotes CD8(+) dendritic cell (DC) maturation and migration to draining lymph nodes. The peripherally released mast cell TNF further critically boosts the CD8(+) T-cell-priming efficiency of CD8(+) DCs, thereby linking mast cell effects on T cells to DC modulation. Collectively, our findings identify the distinct potential of mast cell TNF to amplify CD8(+) DC functionality and CD8(+) T-cell-dominated adaptive immunity, which may be of great importance for immunotherapy and vaccination approaches.
语言:: eng
DOI:: 10.1016/j.celrep.2015.08.078

文献库文献相关信息