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题目:: Trajectories of cell-cycle progression from fixed cell populations.
作者:: Gut(Gabriele),Tadmor(Michelle D),Pe'er(Dana),Pelkmans(Lucas),Liberali(Prisca)
状态:: 发布时间2015-09-30 , 更新时间 2016-06-03
期刊:: Nat Methods
摘要:: An accurate dissection of sources of cell-to-cell variability is crucial for quantitative biology at the single-cell level but has been challenging for the cell cycle. We present Cycler, a robust method that constructs a continuous trajectory of cell-cycle progression from images of fixed cells. Cycler handles heterogeneous microenvironments and does not require perturbations or genetic markers, making it generally applicable to quantifying multiple sources of cell-to-cell variability in mammalian cells.
语言:: eng
DOI:: 10.1038/nmeth.3545

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