Escaping Negative Selection: ILC You in the Gut.

Immunity ·Vol. 43 ·No. 1 ·2015-07-21 ·Pages 12-4

Farkas AM, Ivanov II

Abstract

How commensal-specific T cells are controlled in the periphery is poorly understood. In a recent issue of Science, Hepworth et al. (2015) show that ILC3s induce apoptosis of microbiota-specific CD4 T cells in a form of extrathymic negative selection.

MeSH Terms

Animals Bacteria/immunology CD4-Positive T-Lymphocytes/immunology Colon/microbiology Female Histocompatibility Antigens Class II/immunology Humans Immunity, Innate Inflammatory Bowel Diseases/microbiology Male

Chemicals

Histocompatibility Antigens Class II

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Farkas Adam M

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

Ivanov Ivaylo I

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: ii2137@cumc.columbia.edu.

References (10)

10 references, click to expand

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.
Science. 2014 Mar 28;343(6178):1249288 PMID: 24625929
Contextual functions of antigen-presenting cells in the gastrointestinal tract.
Immunol Rev. 2014 May;259(1):75-87 PMID: 24712460
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.
Immunity. 2014 Apr 17;40(4):594-607 PMID: 24684957
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.
Nat Commun. 2015;6:5862 PMID: 25575242
Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.
Science. 2015 May 29;348(6238):1031-5 PMID: 25908663
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.
Nature. 2013 Jun 6;498(7452):113-7 PMID: 23698371
Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria.
Science. 2004 Mar 12;303(5664):1662-5 PMID: 15016999
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19256-61 PMID: 19889972
Immune adaptations that maintain homeostasis with the intestinal microbiota.
Nat Rev Immunol. 2010 Mar;10(3):159-69 PMID: 20182457
Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses.
Science. 2010 Jun 25;328(5986):1705-9 PMID: 20576892

Article Info

Journal

Immunity

Abbr.

Immunity

ISSN

1097-4180

DOI

10.1016/j.immuni.2015.07.006

ii2137@cumc.columbia.edu

Published

2015-07-21

Pages

12-4

Language

English

Region

United States

NLM ID

9432918

PMCID

PMC4767161

Subset

Grants

NIDDK NIH HHS · R01 DK098378 · United States

Corrections

CommentOn

PMID: 25908663

External Links

PubMed source DOI: 10.1016/j.immuni.2015.07.006 PMC Full Text View journal details

Analysis Services

Escaping Negative Selection: ILC You in the Gut.

Contact

WeChat Official Account