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题目:: CKS2 in human cancers: Clinical roles and current perspectives (Review).
作者:: You(Hanyu),Lin(Huayue),Zhang(Zhongying)
状态:: 发布时间2015-07-02 , 更新时间 2015-07-05
期刊:: Mol Clin Oncol
摘要:: Cyclin-dependent kinase subunit 2 (CKS2) is indicated in the processes of cell cycle and cell proliferation. Through these processes, is identified as a cancer gene, but its role has not been well reviewed. The aim of the present study was to summarize the clinicopathological significance and the molecular mechanisms of in human cancers. Its expression was upregulated in the majority of the types of cancer studied. was shown to have a function in cancers of the digestive tract, genital tract, thyroid, nerve and certain other types of cancer. can promote progression of certain cancers via positive control of proliferation, invasion and migration. Downregulation of induces cancer cell apoptosis. can change a multitude of cellular mechanisms in cancer pathogenesis by regulating the gene translation of numerous validated targets, such as , cyclin A, cyclin B1, caspase-3 and . In addition, the molecular mechanism that causes aberrant expression of was epigenetic modification of and the Y-box-binding protein 1 () gene. In conclusion, is commonly elevated in cancer, most likely due to its ability to promote cancer cell growth, invasion and migration through regulating certain significant genes. Understanding the mechanisms by which is involved with cancer pathogenesis will be useful in the development of tumor therapy for patients with cancer.
语言:: eng
DOI:

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