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题目:: Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver.
作者:: Chowdhury(Md Kamrul H),Montgomery(Magda K),Morris(Margaret J),Cognard(Emmanuelle),Shepherd(Peter R),Smith(Greg C)
状态:: 发布时间2015-07-24 , 更新时间 2015-07-24
期刊:: Arch Physiol Biochem
摘要:: In the last 20 years the prevalence of metabolic disorders, in particular type 2 diabetes (T2D), has more than doubled. Recently, a strong link between T2D and cancer, in particularly liver cancer has been reported. However, the mechanism connecting the development of type 2 diabetes and cancer remains unknown. One of the biggest drivers of liver cancer is alterations in the Wnt/β-catenin pathway. In this study, we aimed to identify the effect of glucagon on β-catenin in the isolated rat liver. We found glucagon, which is substantially raised in patients with T2D, rapidly phosphorylates β-catenin on serine 552 that is associated with increased expression of genes cyclin D1 (CCND1) and c-Myc (MYC), which are known to be involved in liver cancer. This finding may explain the increased risk of liver cancer in people with T2D.
语言:: eng
DOI:: 10.3109/13813455.2015.1048693

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