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题目:: Regulation of B Cell to Plasma Cell Transition within the Follicular B Cell Response.
作者:: Nera(K-P),Kyläniemi(M K),Lassila(O)
状态:: 发布时间2015-08-19 , 更新时间 2015-08-19
期刊:: Scand J Immunol
摘要:: Persistent humoral immunity depends on the follicular B cell response and on the generation of somatically mutated high-affinity plasma cells and memory B cells. Upon activation by an antigen, cognately activated follicular B cells and follicular T helper (TFH ) cells initiate germinal centre (GC) reaction during which high-affinity effector cells are generated. The differentiation of activated follicular B cells into plasma cells and memory B cells is guided by complex selection events, both at the cellular and molecular level. The transition of B cell into a plasma cell during the GC response involves alterations in the microenvironment and developmental state of the cell, which are guided by cell-extrinsic signals. The developmental cell fate decisions in response to these signals are coordinated by cell-intrinsic gene regulatory network functioning at epigenetic, transcriptional and post-transcriptional levels.
语言:: eng
DOI:: 10.1111/sji.12336

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