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题目:: The Association Between VEGF +936C/T and -634G/C Polymorphisms and Breast Cancer Susceptibility, Tumor Growth, and Metastases: Evidence From 20,728 Subjects.
作者:: Ma(Jianguo),Hu(Weiguo),Zhang(Ping),Sun(Yujing),Wang(Na),Teng(Xiaoyan),Qiao(Qian)
状态:: 发布时间2015-08-05 , 更新时间 2015-08-05
期刊:: Cancer Invest
摘要:: The relation between the polymorphisms of vascular endothelial growth factor (VEGF) and breast cancer remains inconclusive. In our meta-analysis based on 10,340 breast cancer patients and 10,388 controls, we found breast cancer susceptibility was elevated in individuals carrying the VEGF +936C allele, especially in Asians, and the +936CC increases tumor growth. The G allele of -634G/C polymorphism reduces breast cancer susceptibility in Asians, and breast cancer patients of -634GG genotype has decreased tumor growth. These results suggest that both the VEGF +936C/T and -634G/C polymorphisms influence breast cancer susceptibility and tumor growth, instead of metastasis.
语言:: eng
DOI:: 10.3109/07357907.2015.1044664

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