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题目:: MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression.
作者:: Long(Jianting),Ou(Caiwen),Xia(Haoming),Zhu(Yifan),Liu(Dayue)
状态:: 发布时间2015-12-08 , 更新时间 2015-12-08
期刊:: Tumour Biol
摘要:: Breast cancer is one of the most common malignancies and a major cause of cancer-related mortality all over the world. A growing body of reports revealed that microRNAs play essential roles in the progression of cancers. Aberrant expression of miR-503 has been reported in several kinds of cancer. The aim of the current study was to elucidate the role of miR-503 in the pathogenesis of breast cancer. In the present study, our results suggested that miR-503 expression was markedly downregulated in breast cancer tissues and cells. Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1. Together, our findings provide new knowledge regarding the role of miR-503 in the progression of breast cancer and indicate the role of miR-503 as a tumor suppressor microRNA (miRNA) in breast cancer.
语言:: eng
DOI:

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