Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
Neutralisation of macrophage chemoattractant C-C chemokine ligand 2 (CCL2) has shown reduced metastasis and enhanced survival in numerous experimental models of tumorigenesis. However, important new findings reported in Nature by Momo Bentires-Alj's laboratory demonstrate that withdrawal of anti-CCL2 treatment accelerates lung metastasis and death in mice. The study highlights the need to consider longer term consequences of therapeutic intervention of metastatic disease, especially with regard to transient interference with the tumour microenvironment.
14 references, click to expand
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Microenvironmental regulation of metastasis.Nat Rev Cancer. 2009 Apr;9(4):239-52 PMID: 19279573
-
Monocyte chemoattractant protein-1 serum levels in patients with breast cancer.Tumour Biol. 2004 Jan-Apr;25(1-2):14-7 PMID: 15192307
-
Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells.PLoS One. 2013;8(3):e58791 PMID: 23527025
-
Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells.Am J Respir Cell Mol Biol. 2011 Feb;44(2):230-7 PMID: 20395632
-
Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer.J Immunol. 2001 Jan 1;166(1):678-89 PMID: 11123353
-
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis.Nature. 2011 Jul 14;475(7355):222-5 PMID: 21654748
-
Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma.Cancer. 2001 Sep 1;92(5):1085-91 PMID: 11571719
-
A role for CCL2 in both tumor progression and immunosurveillance.Oncoimmunology. 2013 Jul 1;2(7):e25474 PMID: 24073384
-
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.Nature. 2014 Nov 6;515(7525):130-3 PMID: 25337873
-
A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors.Cancer Chemother Pharmacol. 2013 Apr;71(4):1041-50 PMID: 23385782
-
Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption.Cancer Res. 2007 Apr 15;67(8):3646-53 PMID: 17440076
-
Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic γδ T lymphocytes to tumor beds.J Immunol. 2013 Jun 15;190(12):6673-80 PMID: 23686489
-
Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression.Int J Cancer. 2009 Sep 15;125(6):1276-84 PMID: 19479998
-
Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo.Cancer Res. 2007 Oct 1;67(19):9417-24 PMID: 17909051
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