| GeneLibs

题目:: Common marmoset CD117+ hematopoietic cells possess multipotency.
作者:: Shimada(Shin),Nunomura(Satoshi),Mori(Shuya),Suemizu(Hiroshi),Itoh(Toshio),Takabayashi(Shuji),Okada(Yoshinori),Yahata(Takashi),Shiina(Takashi),Katoh(Hideki),Suzuki(Ryuji),Tani(Kenzaburo),Ando(Kiyoshi),Yagita(Hideo),Habu(Sonoko),Sasaki(Erika),Kametani(Yoshie)
状态:: 发布时间2015-10-30 , 更新时间 2015-10-30
期刊:: Int Immunol
摘要:: Analysis of the hematopoiesis of non-human primates is important to clarify the evolution of primate-specific hematopoiesis and immune regulation. However, the engraftment and development of the primate hematopoietic system are well-documented only in humans and are not clear in non-human primates. Callithrix jacchus (common marmoset, CM) is a New World monkey with a high rate of pregnancy and small size that lives in closed colonies. As stem cell factor (SCF) is an essential molecule for hematopoietic stem cell development in mice and humans, we focused on CD117, the SCF receptor, and examined whether CD117-expressing cells possess the hematopoietic stem/progenitor cell characteristics of newborn marmoset-derived hematopoietic cells that can develop into T cells and B cells. When CD117(+) cell fractions of the bone marrow were transplanted into immunodeficient NOD (non-obese diabetic)/Shi-scid, common γc-null (NOG) mice, these cells engrafted efficiently in the bone marrow and spleens of the NOG mice. The CD117(+) cells developed into myeloid lineage cells, CD20(+) B cells and CD3(+) T cells, which could express CM cytokines in vivo. The development of B cells did not precede that of T cells. The development of CD8(+) T cells was dominant in NOG mice. The engraftment was comparable for both CD117(+)CD34(+) cells and CD117(+)CD34(-) cells. These results suggest that the CD117(+) cell fraction can differentiate into all three cell lineages, and the development of marmoset immunity in the xenogeneic environment follows diverse developmental pathways compared with human immunity.
语言:: eng
DOI:: 10.1093/intimm/dxv031

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息