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题目:: Metabolomics of cancer cell cultures to assess the effects of dietary phytochemicals.
作者:: Brasili(Elisa),Filho(Valdir Cechinel)
状态:: 发布时间2015-05-15 , 更新时间 2015-05-16
期刊:: Crit Rev Food Sci Nutr
摘要:: Cancer is a multifactorial disease and is a major cause of morbidity and mortality worldwide. Dietary phytochemicals have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Several studies have been performed to elucidate the effects of the dietary phytochemicals on cancer metabolism and many molecular targets of phytochemicals have been discovered. Despite remarkable progresses, their effects on cancer metabolism have not yet been fully clarified. The recent development of metabolomics allowed to probe much further into the metabolism of cancer highlighting altered metabolic pathways and offering a new powerful tool to investigate the cancer disease. In this Review, we discuss the main metabolic alterations of cancer cell and the potentiality of phytochemicals as promising modulators of cancer metabolism. We will focus on the application of NMR-based metabolomics on breast and hepatocellular cancer cell lines to evaluate the impact of curcumin and resveratrol on cancer metabolome with the aims to demonstrate the premise of this approach to provide useful information for a better understanding of impact of diet components on cancer disease.
语言:: eng
DOI:: 10.1080/10408398.2014.964799

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