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题目:: Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors.
作者:: Thiault(Nicolas),Darrigues(Julie),Adoue(Véronique),Gros(Marine),Binet(Bénédicte),Perals(Corine),Leobon(Bertrand),Fazilleau(Nicolas),Joffre(Olivier P),Robey(Ellen A),van Meerwijk(Joost P M),Romagnoli(Paola)
状态:: 发布时间2015-05-20 , 更新时间 2015-05-20
期刊:: Nat Immunol
摘要:: Most T lymphocytes, including regulatory T cells (Treg cells), differentiate in the thymus. The age-dependent involution of this organ leads to decreasing production of T cells. Here we found that the output of new Treg cells from the thymus decreased substantially more than that of conventional T cells. Peripheral mouse and human Treg cells recirculated back to the thymus, where they constituted a large proportion of the pool of Treg cells and displayed an activated and differentiated phenotype. In the thymus, the recirculating cells exerted their regulatory function by inhibiting interleukin 2 (IL-2)-dependent de novo differentiation of Treg cells. Thus, Treg cell development is controlled by a negative feedback loop in which mature progeny cells return to the thymus and restrain development of precursors of Treg cells.
语言:: eng
DOI:: 10.1038/ni.3150

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