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题目:: Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma.
作者:: Boesaard(Ewout P),Vogelaar(Ingrid P),Bult(Peter),Wauters(Carla Ap),van Krieken(J Han Jm),Ligtenberg(Marjolijn Jl),van der Post(Rachel S),Hoogerbrugge(Nicoline)
状态:: 发布时间2015-05-04 , 更新时间 2015-05-11
期刊:: Hered Cancer Clin Pract
摘要:: MUTYH-associated polyposis (MAP) is an autosomal recessive disease, which predisposes to polyposis and colorectal cancer. There is a trend towards an increased risk of breast cancer in MAP patients, with a remarkable proportion of papillary breast cancers. To determine whether MUTYH mutations are associated with this specific and rare type of breast cancer, 53 unselected patients with papillary breast cancer were analyzed for founder mutations in the MUTYH gene. No germline mutations were identified, indicating that biallelic MUTYH mutations are not a frequent underlying cause for the development of papillary carcinomas of the breast.
语言:: eng
DOI:

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