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题目:: Kinetics of lymphocyte subpopulations in allogeneic grafted scales of ginbuna crucian carp.
作者:: Shibasaki(Yasuhiro),Matsuura(Yuta),Toda(Hideaki),Imabayashi(Nozomi),Nishino(Tatsuyuki),Uzumaki(Kosuke),Hatanaka(Chihiro),Yabu(Takeshi),Moritomo(Tadaaki),Nakanishi(Teruyuki)
状态:: 发布时间2015-06-06 , 更新时间 2015-06-06
期刊:: Dev Comp Immunol
摘要:: In mammals the rejection of allografts is primarily accomplished by cell-mediated immunity including T cells. Recently, considerable studies reveal the existence of helper and cytotoxic T cell subsets in fish. Here we investigate the kinetics of CD4(+) and CD8α(+) T cells along with sIgM(+) cells and phagocytic cells in an allogeneic scale graft model using ginbuna crucian carp for understanding the mechanisms of cell-mediated immune response. The results showed that CD4(+) T cells first infiltrated into allogeneic scales followed by CD8α(+) and sIgM(+) cells, and finally phagocytic cells appeared in the graft. Furthermore, most of the CD8α(+) T cells appeared on the border of the allografted scales at the time of rejection. These results suggest that T cells play crucial roles and work together with other cell types for completion of allograft rejection.
语言:: eng
DOI:: 10.1016/j.dci.2015.04.013

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