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PMID: 25887522 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The ensembl regulatory build.

Genome biology ·Vol. 16 ·2015-03-24 ·Pages 56

Zerbino DR, Wilder SP, Johnson N, Juettemann T, Flicek PR

Abstract

Most genomic variants associated with phenotypic traits or disease do not fall within gene coding regions, but in regulatory regions, rendering their interpretation difficult. We collected public data on epigenetic marks and transcription factor binding in human cell types and used it to construct an intuitive summary of regulatory regions in the human genome. We verified it against independent assays for sensitivity. The Ensembl Regulatory Build will be progressively enriched when more data is made available. It is freely available on the Ensembl browser, from the Ensembl Regulation MySQL database server and in a dedicated track hub.

MeSH Terms
Computational Biology Databases, Genetic Epigenesis, Genetic/genetics Genomics Humans Internet Software Transcription Factors/genetics User-Computer Interface
Chemicals
Transcription Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Zerbino Daniel R
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. zerbino@ebi.ac.uk.
Wilder Steven P
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. swilder@ebi.ac.uk.
Johnson Nathan
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. njohnson@ebi.ac.uk.
Juettemann Thomas
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. juettemann@ebi.ac.uk.
Flicek Paul R
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. flicek@ebi.ac.uk.
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Article Info
Journal
Genome biology
Abbr.
Genome Biol
ISSN
1474-760X
DOI
10.1186/s13059-015-0621-5
Email
zerbino@ebi.ac.uk
swilder@ebi.ac.uk
njohnson@ebi.ac.uk
juettemann@ebi.ac.uk
flicek@ebi.ac.uk
Published
2015-03-24
Epub
2015-00-24
Pages
56
Language
English
Region
England
NLM ID
100960660
PMCID
PMC4407537
Subset
IM
Grants
NHGRI NIH HHS · 1U01 HG004695 · United States
Wellcome Trust · 095908 · United Kingdom
Biotechnology and Biological Sciences Research Council · BB/I025360/2 · United Kingdom
NHGRI NIH HHS · U01 HG004695 · United States
NHGRI NIH HHS · 5U01HG004695 · United States
External Links
PubMed source DOI: 10.1186/s13059-015-0621-5 PMC Full Text View journal details
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