| GeneLibs

题目:: Vasohibin-1 suppresses colon cancer.
作者:: Liu(Shuai),Han(Bing),Zhang(Qunyuan),Dou(Jie),Wang(Fang),Lin(Wenli),Sun(Yuping),Peng(Guangyong)
状态:: 发布时间2015-04-30 , 更新时间 2015-06-27
期刊:: Oncotarget
摘要:: Vasohibin-1 (VASH1) is an endogenous angiogenesis inhibitor.However, the clinical relevance of VASH1 in colon cancer and its regulations on cancer angiogenesis and cancer cell biological characteristics are still unknown. Here we showed that stromal VASH1 levels were negatively correlated with tumor size, advanced clinical stage and distant metastases in colon cancer patients. Overexpression of VASH1 in colon cancer cells induced apoptosis and senescence, inhibiting cancer cell growth and colony formation in vitro and tumor growth in vivo. In addition, knockdown of VASH1 in cancer cells promoted cell growth, adhesion and migration in vitro, and enhanced tumorigenesis and metastasis in vivo.
语言:: eng
DOI:: 10.18632/oncotarget.3493

文献库文献相关信息