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PMID: 2579383 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 3 ·1985-02-00 ·Pages 945-7

Mobley P, Greengard P

Abstract

Noradrenaline, apparently working through activation of beta-adrenergic receptors, alters the state of phosphorylation of a substantial proportion of synapsin I in rat frontal cortex. Since synapsin I is enriched in virtually all axon terminals in this brain region, the results indicate that noradrenaline, a sparsely distributed neurotransmitter, affects a large number of axon terminals in this region. The results also suggest that noradrenaline receptors are present on a substantial percentage of all axon terminals in the cerebral cortex, despite the low density of noradrenergic fibers present. The data support the view that noradrenaline may serve a paracrine function.

MeSH Terms
1-Methyl-3-isobutylxanthine/pharmacology Animals Axons/drug effects Cerebral Cortex/cytology Isoproterenol/pharmacology Male Nerve Tissue Proteins/metabolism Norepinephrine/pharmacology Phosphorylation Rats Rats, Inbred Strains Receptors, Adrenergic, beta/metabolism Stereoisomerism Synapsins
Chemicals
Nerve Tissue Proteins Receptors, Adrenergic, beta Synapsins Isoproterenol 1-Methyl-3-isobutylxanthine Norepinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mobley P
Greengard P
References (20)
20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.3.945
Published
1985-02-00
Pages
945-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC397164
Subset
IM
Grants
NIMH NIH HHS · MH-17387 · United States
NINDS NIH HHS · NS-08440 · United States
External Links
PubMed source DOI: 10.1073/pnas.82.3.945 PMC Full Text View journal details
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