The importance of cooperation: partnerless NFAT induces T cell exhaustion.

Immunity ·Vol. 42 ·No. 2 ·2015-02-17 ·Pages 203-205

Bengsch B, Wherry EJ

Abstract

Downstream of costimulatory pathways, complexes of transcription factors NFAT and AP-1 promote effector T cell differentiation. In this issue of Immunity, Martinez et al. report that monomeric NFAT binding in the absence of a transcriptional partner induces a gene expression program involved in T cell exhaustion.

MeSH Terms

Animals CD8-Positive T-Lymphocytes/immunology Clonal Anergy/genetics NFATC Transcription Factors/physiology Recombinant Proteins/pharmacology Transcription Factor AP-1/metabolism

Chemicals

NFATC Transcription Factors Nfatc2 protein, mouse Recombinant Proteins Transcription Factor AP-1

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bengsch Bertram

Institute for Immunology, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Wherry E John

Institute for Immunology, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: wherry@mail.med.upenn.edu.

Article Info

Journal

Immunity

Abbr.

Immunity

ISSN

1097-4180

DOI

10.1016/j.immuni.2015.01.023

wherry@mail.med.upenn.edu

Published

2015-02-17

Pages

203-205

Language

English

Region

United States

NLM ID

9432918

Subset

Corrections

CommentOn

PMID: 25680272

External Links

PubMed source DOI: 10.1016/j.immuni.2015.01.023 View journal details

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The importance of cooperation: partnerless NFAT induces T cell exhaustion.

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