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PMID: 2566917 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cyclin synthesis drives the early embryonic cell cycle.

Nature ·Vol. 339 ·No. 6222 ·1989-05-25 ·Pages 275-80

Murray AW, Kirschner MW

Abstract

We have produced extracts of frog eggs that can perform multiple cell cycles in vitro. Destruction of the endogenous messenger RNA arrests the extracts in interphase. The addition of exogenous cyclin mRNA is sufficient to produce multiple cell cycles. The newly synthesized cyclin protein accumulates during each interphase and is degraded at the end of each mitosis.

MeSH Terms

Animals Cell Cycle Cell Nucleus/ultrastructure Embryo, Nonmammalian/cytology,physiology Female Growth Substances/physiology Interphase Maturation-Promoting Factor Metaphase Mitosis Nuclear Proteins/biosynthesis,genetics,physiology Proliferating Cell Nuclear Antigen RNA, Messenger/genetics Xenopus

Chemicals

Growth Substances Nuclear Proteins Proliferating Cell Nuclear Antigen RNA, Messenger Maturation-Promoting Factor

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Murray A W

Department of Biochemistry and Biophysics, School of Medicine, University of California, San Francisco 94143-0448.

Kirschner M W

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/339275a0

Published

1989-05-25

Pages

275-80

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/339275a0 View journal details

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Cyclin synthesis drives the early embryonic cell cycle.

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