Home LiteratureArticle Details

PMID: 2563350 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Confirmation of linkage of Friedreich ataxia to chromosome 9 and identification of a new closely linked marker.

Genomics ·Vol. 4 ·No. 1 ·1989-01-00 ·Pages 110-1

Fujita R, Agid Y, Trouillas P, Seck A, Tommasi-Davenas C, Driesel AJ, Olek K, Grzeschik KH, Nakamura Y, Mandel JL, Hanauer A

Abstract

A linkage analysis with chromosome 9 markers was performed in 33 families with Friedreich ataxia (FA). Linkage with D9S15, previously established by S. Chamberlain et al. (1988, Nature London 334:248-249) was confirmed in our sample (z(theta) = 6.82 at theta = 0.02) while INFB (interferon-beta gene) shows looser linkage. An additional marker, D9S5, was also shown to be closely linked to FA (z(theta) = 5.77 at theta = 0.00).

MeSH Terms

Chromosomes, Human, Pair 9 Deoxyribonucleases, Type II Site-Specific Friedreich Ataxia/genetics Genetic Linkage Genetic Markers Humans Interferon Type I/genetics Polymorphism, Restriction Fragment Length

Chemicals

Genetic Markers Interferon Type I Deoxyribonucleases, Type II Site-Specific TCGA-specific type II deoxyribonucleases

Authors & Affiliations

11 authors, click to expand affiliations / ORCID

Fujita R

U.184 INSERM, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Faculté de Médecine, Strasbourg, France.

Agid Y

Trouillas P

Seck A

Tommasi-Davenas C

Driesel A J

Olek K

Grzeschik K H

Nakamura Y

Mandel J L

Hanauer A

Article Info

Journal

Genomics

Abbr.

Genomics

ISSN

0888-7543

DOI

10.1016/0888-7543(89)90323-6

Published

1989-01-00

Pages

110-1

Language

English

Region

United States

NLM ID

8800135

Subset

External Links

PubMed source DOI: 10.1016/0888-7543(89)90323-6 View journal details

Analysis Services

Confirmation of linkage of Friedreich ataxia to chromosome 9 and identification of a new closely linked marker.

Contact

WeChat Official Account