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题目:: Unipotent, Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult mice.
作者:: Wright(Margaret C),Reed-Geaghan(Erin G),Bolock(Alexa M),Fujiyama(Tomoyuki),Hoshino(Mikio),Maricich(Stephen M)
状态:: 发布时间2015-02-03 , 更新时间 2016-10-19
期刊:: J Cell Biol
摘要:: Resident progenitor cells in mammalian skin generate new cells as a part of tissue homeostasis. We sought to identify the progenitors of Merkel cells, a unique skin cell type that plays critical roles in mechanosensation. We found that some Atoh1-expressing cells in the hairy skin and whisker follicles are mitotically active at embryonic and postnatal ages. Genetic fate-mapping revealed that these Atoh1-expressing cells give rise solely to Merkel cells. Furthermore, selective ablation of Atoh1(+) skin cells in adult mice led to a permanent reduction in Merkel cell numbers, demonstrating that other stem cell populations are incapable of producing Merkel cells. These data identify a novel, unipotent progenitor population in the skin that gives rise to Merkel cells both during development and adulthood.
语言:: eng
DOI:

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