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PMID: 25616065 Published · ppublish English Journal Article Comment

ZMP: a master regulator of one-carbon metabolism.

Molecular cell ·Vol. 57 ·No. 2 ·2015-01-22 ·Pages 203-4

Ducker GS, Rabinowitz JD

Abstract

In this issue, Kim et al. (2015) show that ZMP (5-aminoimidazole-4-carboxamide ribonucleotide) binds to and activates a conserved riboswitch to regulate expression of one-carbon metabolism genes.

MeSH Terms
Animals Endosomes/enzymology Humans Male Mechanistic Target of Rapamycin Complex 1 Multiprotein Complexes/physiology Phagosomes/enzymology Protein Processing, Post-Translational TOR Serine-Threonine Kinases/physiology Tumor Suppressor Proteins/metabolism
Chemicals
Multiprotein Complexes Tumor Suppressor Proteins UVRAG protein, human Mechanistic Target of Rapamycin Complex 1 TOR Serine-Threonine Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ducker Gregory S
The Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Rabinowitz Joshua D
The Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address: joshr@genomics.princeton.edu.
References (9)
9 references, click to expand
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Article Info
Journal
Molecular cell
Abbr.
Mol Cell
ISSN
1097-4164
DOI
10.1016/j.molcel.2015.01.012
Email
joshr@genomics.princeton.edu
Published
2015-01-22
Pages
203-4
Language
English
Region
United States
NLM ID
9802571
PMCID
PMC4470396
Subset
IM
Grants
NCI NIH HHS · R01 CA163591 · United States
Corrections
CommentOn
PMID: 25533187
External Links
PubMed source DOI: 10.1016/j.molcel.2015.01.012 PMC Full Text View journal details
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