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PMID: 25615866 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Collaborative computational project for electron cryo-microscopy.

Acta crystallographica. Section D, Biological crystallography ·Vol. 71 ·No. Pt 1 ·2015-01-01 ·Pages 123-6

Wood C, Burnley T, Patwardhan A, Scheres S, Topf M, Roseman A, Winn M

Abstract

The Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has recently been established. The aims of the project are threefold: to build a coherent cryoEM community which will provide support for individual scientists and will act as a focal point for liaising with other communities, to support practising scientists in their use of cryoEM software and finally to support software developers in producing and disseminating robust and user-friendly programs. The project is closely modelled on CCP4 for macromolecular crystallography, and areas of common interest such as model fitting, underlying software libraries and tools for building program packages are being exploited. Nevertheless, cryoEM includes a number of techniques covering a large range of resolutions and a distinct project is required. In this article, progress so far is reported and future plans are discussed.

Keywords
CCP-EM Collaborative Computational Project for Electron cryo-Microscopy
MeSH Terms
Cooperative Behavior Cryoelectron Microscopy/methods
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Wood Chris
Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, England.
Burnley Tom
Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, England.
Patwardhan Ardan
European Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, England.
Scheres Sjors
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, England.
Topf Maya
Biological Sciences at Birkbeck, University of London, Malet Street, London WC1E 7HX, England.
Roseman Alan
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, England.
Winn Martyn
Scientific Computing Department, Science and Technology Facilities Council, Daresbury Laboratory, Warrington WA4 4AD, England.
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Article Info
Journal
Acta crystallographica. Section D, Biological crystallography
Abbr.
Acta Crystallogr D Biol Crystallogr
ISSN
1399-0047
DOI
10.1107/S1399004714018070
Published
2015-01-01
Epub
2015-00-01
Pages
123-6
Language
English
Region
United States
NLM ID
9305878
PMCID
PMC4304692
Subset
IM
Grants
Medical Research Council · MR/L007835/1 · United Kingdom
Medical Research Council · MR/J000825/1 · United Kingdom
NIGMS NIH HHS · R01 GM079429 · United States
Medical Research Council · G0600084 · United Kingdom
Medical Research Council · MC_UP_A025_1013 · United Kingdom
Biotechnology and Biological Sciences Research Council · BB/G022577/1 · United Kingdom
External Links
PubMed source DOI: 10.1107/S1399004714018070 PMC Full Text View journal details
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