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PMID: 2556851 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs.

Virology ·Vol. 173 ·No. 2 ·1989-12-00 ·Pages 733-5

Turk SR, Kik NA, Birch GM, Chiego DJ, Shipman C

Abstract

Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6 delta, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.

MeSH Terms

Animals Cell Line Disease Models, Animal Female Guinea Pigs Herpes Simplex/microbiology Histocytochemistry Mutation Ribonucleotide Reductases/genetics Simplexvirus/enzymology,genetics,physiology Skin/pathology Virus Replication

Chemicals

Ribonucleotide Reductases

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Turk S R

Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109.

Kik N A

Birch G M

Chiego D J

Shipman C

Article Info

Journal

Virology

Abbr.

Virology

ISSN

0042-6822

DOI

10.1016/0042-6822(89)90588-6

Published

1989-12-00

Pages

733-5

Language

English

Region

United States

NLM ID

0110674

Subset

Grants

NIDCR NIH HHS · DE-08510 · United States

External Links

PubMed source DOI: 10.1016/0042-6822(89)90588-6 View journal details

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Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs.

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