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题目:: Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report.
作者:: Pujol-Gimenez(Jonai),de Heredia(Fátima Pérez),Idoate(Miguel Angel),Airley(Rachel),Lostao(María Pilar),Evans(Andrew Robert)
状态:: 发布时间2015-01-06 , 更新时间 2015-01-13
期刊:: J Cancer
摘要:: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells.,GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model.,GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism.,The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.
语言:: eng
DOI:

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