| GeneLibs

题目:: Assessment of RIT2 rs12456492 association with Parkinson's disease in Mainland China.
作者:: Liu(Zhen-hua),Guo(Ji-feng),Wang(Ya-qin),Li(Kai),Sun(Qi-ying),Xu(Qian),Yan(Xin-xiang),Xu(Chang-shui),Tang(Bei-sha)
状态:: 发布时间2015-03-02 , 更新时间 2015-03-02
期刊:: Neurobiol Aging
摘要:: A recent meta-analysis of genome-wide association studies in Parkinson's disease (PD) has identified the rs12456492 variant in RIT2 as a new susceptibility loci. Because the characteristics of this locus in a Han Chinese population from mainland China was still unknown, we performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals. In total, 933 subjects comprising 460 PD patients and 473 control subjects were genotyped. We found a significant difference in the distributions of genotype and allele between PD and control groups (genotype p = 0.008, allele p = 0.007, odds ratio = 1.296, 95% confidence interval = 1.075-1.563). This study replicates the association between rs12456492 variant and risk of developing PD in a Han Chinese population.
语言:: eng
DOI:: 10.1016/j.neurobiolaging.2014.12.012

文献库文献相关信息