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题目:: T cell exhaustion and Interleukin 2 downregulation.
作者:: Balkhi(Mumtaz Y),Ma(Qiangzhong),Ahmad(Shazia),Junghans(Richard P)
状态:: 发布时间2015-01-16 , 更新时间 2015-01-16
期刊:: Cytokine
摘要:: T cells reactive to tumor antigens and viral antigens lose their reactivity when exposed to the antigen-rich environment of a larger tumor bed or viral load. Such non-responsive T cells are termed exhausted. T cell exhaustion affects both CD8+ and CD4+ T cells. T cell exhaustion is attributed to the functional impairment of T cells to produce cytokines, of which the most important may be Interleukin 2 (IL2). IL2 performs functions critical for the elimination of cancer cells and virus infected cells. In one such function, IL2 promotes CD8+ T cell and natural killer (NK) cell cytolytic activities. Other functions include regulating naïve T cell differentiation into Th1 and Th2 subsets upon exposure to antigens. Thus, the signaling pathways contributing to T cell exhaustion could be linked to the signaling pathways contributing to IL2 loss. This review will discuss the process of T cell exhaustion and the signaling pathways that could be contributing to T cell exhaustion.
语言:: eng
DOI:: 10.1016/j.cyto.2014.11.024

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