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题目:: The roles of AXIN2 in tumorigenesis and epigenetic regulation.
作者:: Li(Shuang),Wang(Chunpeng),Liu(Xiaodong),Hua(Shucheng),Liu(Xin)
状态:: 发布时间2015-05-14 , 更新时间 2015-05-14
期刊:: Fam Cancer
摘要:: AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on. The epigenetic regulation provides new insights for further exploring the pathogenesis of tumor. In this paper, the roles of AXIN2 in tumorigenesis, AXIN2 methylation, ubiquitination and siRNA/RNA regulation will be reviewed.
语言:: eng
DOI:: 10.1007/s10689-014-9775-7

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