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PMID: 25483405 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Pervasive transcription: detecting functional RNAs in bacteria.

Transcription ·Vol. 5 ·No. 4 ·2014-00-00 ·Pages e944039

Lybecker M, Bilusic I, Raghavan R

Abstract

Pervasive, or genome-wide, transcription has been reported in all domains of life. In bacteria, most pervasive transcription occurs antisense to protein-coding transcripts, although recently a new class of pervasive RNAs was identified that originates from within annotated genes. Initially considered to be non-functional transcriptional noise, pervasive transcription is increasingly being recognized as important in regulating gene expression. The function of pervasive transcription is an extensively debated question in the field of transcriptomics and regulatory RNA biology. Here, we highlight the most recent contributions addressing the purpose of pervasive transcription in bacteria and discuss their implications.

Keywords
Hfq RNA RNase III antisense transcription asRNA asRNA antisense RNA double-stranded RNA dsRNA double-stranded RNA intraRNA intragenic RNA ncRNA non-coding RNA pervasive transcription promoter sigma factor spurious transcription transcriptome
MeSH Terms
Bacteria/genetics,metabolism Bacterial Proteins/metabolism Host Factor 1 Protein/metabolism RNA Processing, Post-Transcriptional RNA, Antisense/metabolism RNA, Bacterial/metabolism Ribonuclease III/metabolism Sigma Factor/metabolism Transcription, Genetic
Chemicals
Bacterial Proteins Host Factor 1 Protein RNA, Antisense RNA, Bacterial Sigma Factor Ribonuclease III
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lybecker Meghan
a Department of Biochemistry and Cell Biology ; Max F Perutz Laboratories; University of Vienna ; Vienna, Austria.
Bilusic Ivana
Raghavan Rahul
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Article Info
Journal
Transcription
Abbr.
Transcription
ISSN
2154-1272
DOI
10.4161/21541272.2014.944039
Published
2014-00-00
Epub
2014-00-30
Pages
e944039
Language
English
Region
United States
NLM ID
101530967
PMCID
PMC4581347
Subset
IM
Grants
Austrian Science Fund FWF · I 538 · Austria
External Links
PubMed source DOI: 10.4161/21541272.2014.944039 PMC Full Text View journal details
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