| GeneLibs

题目:: Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells.
作者:: Weissbein(Uri),Ben-David(Uri),Benvenisty(Nissim)
状态:: 发布时间2014-12-06 , 更新时间 2016-05-18
期刊:: Cell Stem Cell
摘要:: Neural cells can be derived either from pluripotent or adult stem cells via differentiation or by transdifferentiation from other cell types with the aid of tissue regulators. We compared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual karyotyping (e-karyotyping). We detected notable genomic instability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated cells seemed more chromosomally stable, except if they were reprogrammed using pluripotency factors.
语言:: eng
DOI:: 10.1016/j.stem.2014.10.018

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