Home LiteratureArticle Details
PMID: 2546846 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Enalapril retards glomerular basement membrane thickening and albuminuria in the diabetic rat.

Diabetologia ·Vol. 32 ·No. 5 ·1989-05-00 ·Pages 326-8

Cooper ME, Allen TJ, Macmillan PA, Clarke BE, Jerums G, Doyle AE

Abstract

This study has evaluated the effects of the angiotensin converting enzyme inhibitor Enalapril on glomerular ultrastructure and albuminuria in normotensive and hypertensive diabetic rats. Streptozotocin-diabetes was induced in Wistar Kyoto and spontaneously hypertensive rats. Enalapril was administered in drinking water in diabetic normotensive, control hypertensive and diabetic hypertensive rats. Enalapril therapy prevented an increase in glomerular basement membrane thickness in diabetic normotensive, control hypertensive and diabetic hypertensive rats without any significant effect on fractional mesangial volume. Enalapril decreased albuminuria in diabetic normotensive, control hypertensive and diabetic hypertensive rats. Thus, enalapril retards the development of glomerular basement membrane thickening and albuminuria in the rat, in the presence or absence of hypertension.

MeSH Terms
Albuminuria Animals Basement Membrane/drug effects,pathology,ultrastructure Blood Pressure Diabetes Mellitus, Experimental/drug therapy,pathology Diabetic Nephropathies/pathology,prevention & control Enalapril/therapeutic use Kidney Glomerulus/drug effects,pathology,ultrastructure Male Rats Rats, Inbred SHR Rats, Inbred WKY Reference Values
Chemicals
Enalapril
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Cooper M E
Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Allen T J
Macmillan P A
Clarke B E
Jerums G
Doyle A E
References (8)
8 references, click to expand
  1. Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.
    J Clin Invest. 1986 Jun;77(6):1925-30 PMID: 3011862
  2. Genetic hypertension accelerates nephropathy in the streptozotocin diabetic rat.
    Am J Hypertens. 1988 Jan;1(1):5-10 PMID: 2835966
  3. Effects of genetic hypertension on diabetic nephropathy in the rat--functional and structural characteristics.
    J Hypertens. 1988 Dec;6(12):1009-16 PMID: 3221096
  4. Glomerular hemodynamics in experimental diabetes mellitus.
    Kidney Int. 1981 Mar;19(3):410-5 PMID: 7241881
  5. Converting enzyme inhibition and kidney function in normotensive diabetic patients with persistent microalbuminuria.
    Br Med J (Clin Res Ed). 1987 Jun 6;294(6585):1448-52 PMID: 3038254
  6. Evidence against increased glomerular pressure initiating diabetic nephropathy.
    Kidney Int. 1987 Apr;31(4):898-905 PMID: 3586496
  7. Current status of capillary basement-membrane disease in diabetes mellitus.
    Diabetes. 1977 Jan;26(1):65-73 PMID: 318626
  8. Effect of captopril on kidney function in insulin-dependent diabetic patients with nephropathy.
    Br Med J (Clin Res Ed). 1986 Aug 23;293(6545):467-70 PMID: 3091164
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00265552
Published
1989-05-00
Pages
326-8
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
Corrections
CommentIn
PMID: 2556309
External Links
PubMed source DOI: 10.1007/BF00265552 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2