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PMID: 2546064 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Leucine zipper in human DNA topoisomerase II.

Molecular endocrinology (Baltimore, Md.) ·Vol. 3 ·No. 3 ·1989-03-00 ·Pages 603-4

Zwelling LA, Perry WM

Abstract

Examination of the amino acid sequence of human DNA topoisomerase II revealed the presence of a leucine zipper, a novel motif found in several proteins localized to the cell nucleus. The presence of this motif in this unique protein may explain some of the normal functions of topoisomerase II as well as the disruption of those functions by antineoplastic drugs.

MeSH Terms

Amino Acid Sequence DNA Topoisomerases, Type II/genetics Humans Leucine Protein Conformation

Chemicals

DNA Topoisomerases, Type II Leucine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Zwelling L A

Department of Medical Oncology, M.D. Anderson Cancer Center, Houston, Texas 77030.

Perry W M

Article Info

Journal

Molecular endocrinology (Baltimore, Md.)

Abbr.

Mol Endocrinol

ISSN

0888-8809

DOI

10.1210/mend-3-3-603

Published

1989-03-00

Pages

603-4

Language

English

Region

United States

NLM ID

8801431

Subset

Grants

NCI NIH HHS · CA-40090 · United States

External Links

PubMed source DOI: 10.1210/mend-3-3-603 View journal details

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Leucine zipper in human DNA topoisomerase II.

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