Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.

The Journal of antibiotics ·Vol. 42 ·No. 6 ·1989-06-00 ·Pages 837-45

Naruse N, Tenmyo O, Tomita K, Konishi M, Miyaki T, Kawaguchi H, Fukase K, Wakamiya T, Shiba T

Abstract

A strain of Streptoverticillium cinnamoneum produced a peptide antibiotic named lanthiopeptin, which contained four unusual amino acids, erythro-beta-hydroxyaspartic acid, mesolanthionine, threo-beta-methyllanthionine and lysinoalanine. Lanthiopeptin showed antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells by cytopathic effect reduction assay. The structure of lanthiopeptin is similar to that of ancovenin.

MeSH Terms

Amino Acid Sequence Amino Acids/analysis Animals Anti-Bacterial Agents/analysis,biosynthesis,isolation & purification,pharmacology Antifungal Agents/analysis,biosynthesis,isolation & purification,pharmacology Antiviral Agents/analysis,biosynthesis,isolation & purification,pharmacology Bacteria/drug effects Chromatography, Gel Cytopathogenic Effect, Viral/drug effects Fermentation Magnetic Resonance Spectroscopy Molecular Sequence Data Peptide Biosynthesis Peptides/analysis,isolation & purification,pharmacology Peptides, Cyclic Simplexvirus/drug effects Soil Microbiology Solubility Spores, Bacterial Streptomycetaceae/growth & development,metabolism,physiology Vero Cells

Chemicals

Amino Acids Anti-Bacterial Agents Antifungal Agents Antiviral Agents Peptides Peptides, Cyclic lanthiopeptin

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Naruse N

Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.

Tenmyo O

Tomita K

Konishi M

Miyaki T

Kawaguchi H

Fukase K

Wakamiya T

Shiba T

Article Info

Journal

The Journal of antibiotics

Abbr.

J Antibiot (Tokyo)

ISSN

0021-8820

DOI

10.7164/antibiotics.42.837

Published

1989-06-00

Pages

837-45

Language

English

Region

Japan

NLM ID

0151115

Subset

External Links

PubMed source DOI: 10.7164/antibiotics.42.837 View journal details

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Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.

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