Remaining challenges in childhood cancer and newer targeted therapeutics.
作者:
Smith(Malcolm A),Reaman(Gregory H)
状态:
发布时间2014-12-01
, 更新时间 2016-12-06
期刊:
Pediatr Clin North Am
摘要:
Despite the enormously important and gratifying advances in cancer treatment outcomes for children with cancer, cancer remains the biggest cause of death from disease in children. Because the etiology and biology of cancers that occur in children differ dramatically from those that occur in adults, the immediate extrapolation of efficacy and safety of new cancer drugs to childhood cancer indications is not possible. We discuss factors that will play key roles in guiding pediatric oncologists as they select lines of research to pursue in their quest for more effective treatments for children with cancer.