Home LiteratureArticle Details
PMID: 2543375 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Differential expression of the alpha and beta retinoic acid receptors in tissues of the rat.

The Biochemical journal ·Vol. 259 ·No. 3 ·1989-05-01 ·Pages 917-9

Rees JL, Daly AK, Redfern CP

Abstract

We have compared the expression of alpha and beta retinoic acid receptors (RAR-alpha and RAR-beta) in different rat tissues. The two cDNA probes for RAR-alpha and RAR-beta each specifically detect two different transcripts. RAR-alpha was expressed in all tissues examined, but, in contrast, the expression of RAR-beta was undetectable in some tissues. The data do not support the idea that RAR-beta is specific to epithelial tissues.

MeSH Terms
Animals Blotting, Northern Carrier Proteins/analysis DNA Probes Liver/analysis Rats Rats, Inbred Strains Receptors, Retinoic Acid Tretinoin
Chemicals
Carrier Proteins DNA Probes Receptors, Retinoic Acid Tretinoin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rees J L
Medical Molecular Biology Group, Medical School, University of Newcastle upon Tyne, U.K.
Daly A K
Redfern C P
References (15)
15 references, click to expand
  1. In vitro binding of retinol to rat-tissue components.
    Proc Natl Acad Sci U S A. 1973 Dec;70(12):3483-7 PMID: 4519641
  2. Retinoic acid and thyroid hormone induce gene expression through a common responsive element.
    Nature. 1988 Nov 17;336(6196):262-5 PMID: 2848197
  3. Mouse actin messenger RNAs. Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA.
    J Biol Chem. 1981 Jan 25;256(2):1008-14 PMID: 6256358
  4. Local application of retinoic acid to the limb bond mimics the action of the polarizing region.
    Nature. 1982 Apr 8;296(5857):564-6 PMID: 7070499
  5. Hybridization of denatured RNA transferred or dotted nitrocellulose paper.
    Methods Enzymol. 1983;100:255-66 PMID: 6194404
  6. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
    Anal Biochem. 1983 Jul 1;132(1):6-13 PMID: 6312838
  7. Characterisation of a retinoic-acid-binding component from F9 embryonal-carcinoma-cell nuclei.
    Eur J Biochem. 1987 Oct 1;168(1):133-9 PMID: 2822401
  8. A human retinoic acid receptor which belongs to the family of nuclear receptors.
    Nature. 1987 Dec 3-9;330(6147):444-50 PMID: 2825025
  9. Identification of a receptor for the morphogen retinoic acid.
    Nature. 1987 Dec 17-23;330(6149):624-9 PMID: 2825036
  10. A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma.
    Nature. 1987 Dec 17-23;330(6149):667-70 PMID: 2825037
  11. Identification of a second human retinoic acid receptor.
    Nature. 1988 Apr 28;332(6167):850-3 PMID: 2833708
  12. A new retinoic acid receptor identified from a hepatocellular carcinoma.
    Nature. 1988 Jun 16;333(6174):669-72 PMID: 2836738
  13. Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes.
    Mol Cell Biol. 1988 Apr;8(4):1775-89 PMID: 2837653
  14. Thyroid hormone receptor alpha isoforms generated by alternative splicing differentially activate myosin HC gene transcription.
    Nature. 1988 Aug 11;334(6182):539-42 PMID: 2841611
  15. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
    Biochemistry. 1979 Nov 27;18(24):5294-9 PMID: 518835
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
Published
1989-05-01
Pages
917-9
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1138606
Subset
IM
Grants
Wellcome Trust · United Kingdom
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com