Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus.

Journal of virology ·Vol. 63 ·No. 7 ·1989-07-00 ·Pages 3161-3

Takahashi K, Sonoda S, Higashi K, Kondo T, Takahashi H, Takahashi M, Yamanishi K

Abstract

Human herpesvirus 6 (HHV-6)-related virus was isolated from CD4+ CD8- and CD3+ CD4+ mature T lymphocytes but could not be isolated from CD4- CD8+, CD4- CD8-, and CD3- T cells in the peripheral blood of exanthem subitum patients. HHV-6-related virus predominantly infected CD4+ CD8+, CD4+ CD8-, and CD3+ CD4+ cells with mature phenotypes and rarely infected CD4- CD8+ cells from cord blood mononuclear cells, which suggested predominant CD4 mature T-lymphocyte tropism of HHV-6-related virus.

MeSH Terms

Antigens, Differentiation, T-Lymphocyte/analysis CD8 Antigens Herpes Simplex/immunology Humans In Vitro Techniques Simplexvirus/immunology T-Lymphocytes/classification,immunology

Chemicals

Antigens, Differentiation, T-Lymphocyte CD8 Antigens

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Takahashi K

Department of Virology, Research Institute for Microbial Diseases, Osaka University, Japan.

Sonoda S

Higashi K

Kondo T

Takahashi H

Takahashi M

Yamanishi K

References (12)

12 references, click to expand

Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1588-92 PMID: 6966400
Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders.
Science. 1986 Oct 31;234(4776):596-601 PMID: 2876520
Purification of human monocytes on gelatin-coated surfaces.
J Immunol Methods. 1986 Dec 24;95(2):273-6 PMID: 3794346
Isolation of human lymphotropic herpesviruses from Uganda.
Lancet. 1987 Aug 15;2(8555):390 PMID: 2886840
A novel lymphotropic herpesvirus.
Lancet. 1987 Aug 15;2(8555):390-2 PMID: 2886841
Human herpesvirus 6 and exanthem subitum.
Lancet. 1988 Jun 25;1(8600):1463 PMID: 2898616
Diverse tropism of HBLV (human herpesvirus 6)
Lancet. 1987 Sep 26;2(8561):743 PMID: 2888966
Concomitant infection by human herpesvirus 6, HTLV-I, and HIV-2.
Lancet. 1988 Mar 26;1(8587):712 PMID: 2895249
In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6).
J Exp Med. 1988 May 1;167(5):1659-70 PMID: 3259254
Identification of human herpesvirus-6 as a causal agent for exanthem subitum.
Lancet. 1988 May 14;1(8594):1065-7 PMID: 2896909
Characteristics of human herpesvirus-6.
J Infect Dis. 1988 Jun;157(6):1271-3 PMID: 3259614
HBLV (or HHV-6) in human cell lines.
Nature. 1987 Sep 17-23;329(6136):207 PMID: 3627265

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.63.7.3161-3163.1989

Published

1989-07-00

Pages

3161-3

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC250875

Subset

External Links

PubMed source DOI: 10.1128/JVI.63.7.3161-3163.1989 PMC Full Text View journal details

Analysis Services

Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus.

Contact

WeChat Official Account